A recent randomized clinical trial from Denmark evaluated weight loss maintenance after one of four 52-week regimens (placebo, once daily liraglutide 3.0 mg alone, supervised exercise alone, or liraglutide plus supervised exercise) in 109 adults with obesity without serious chronic illnesses, including diabetes
it is an unresolved question
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p 40% to meet its primary endpoint, addressing a prominent and longstanding therapeutic challenge, since HFpEF constitutes about half of patients with chronic HF and historically has lacked therapies that modify cardiovascular outcomes
A particularly concerning condition associated with these drugs is stomach paralysis, or gastroparesis, a chronic condition where the stomach takes longer to empty its contents and potentially leads to blockages, resulting in significant discomfort and potentially severe complications
