Central dopaminergic activation is considered the primary driver of these effects
Factors that did not make a difference on developing NAION in the study included age over 65, Black race, male sex, having both type 2 diabetes and obesity or having both diabetes and sleep apnea
Do not exceed two (2) tablets daily
Do not double the dose to "catch up." Mistake 4: Comparing milligrams across peptides A user on semaglutide 2.4 mg who switches to tirzepatide should not start at 2.5 mg thinking it is "about the same." While 2.5 mg happens to be the tirzepatide starting dose, the reasoning should be based on escalation protocol, not milligram matching
14,15 Using the formula for comparing two means, with a two-sided = 0.05 and power = 80%: the minimum required sample size to detect a difference in HbA1c was 39 patients per group (78 total) and the minimum required sample size to detect a difference in BMI was 48 patients per group (96 total)
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