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Unlike previous reviews that have primarily focused on traditional nanocarriers or specific disease states, this review offers a novel and integrated perspective by covering the full spectrum of nanomedicine advancements, from basic science to clinical translation

Theoretical risks of sustained angiogenic stimulation (promoting vascular supply to undetected pathological tissue) grow proportionally with the duration of use, as cumulative VEGF upregulation exceeds the controlled, injury-localized window intended by short-cycle research protocols

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