Front Cell Dev Biol (2020) 8:551681
doi: 10.1021/acsami.2c19904 28 WangQSWangGFZhouJGaoLNCuiYL
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In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration