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How ROSE-010 Works in IBS: Targeted, On-Demand Pain Relief ROSE-010 mimics natural GLP-1 with an optimized, short-acting profile: Fast-acting ( Begins working in 20 minutes ) Short duration ( Clears in a few hours ) Use only when needed during acute episodes for pain resolution Clinical Validation: Proven IBS Pain Relief In Phase 2a Trial Results (Hellstrm et al.), ROSE-010 166 patients with IBS pain (placebo-controlled study) Twice as many patients responded to ROSE-010 vs

General Dosage Guidelines Recommended dose: One tablet (2.5 mg) once daily Can be taken with or without food Should be swallowed whole with water Best taken at the same time each day Dose adjustments may be required in patients with kidney impairment or when used alongside certain medicines

Their further study showed that the presence of a cysteine/cystine shuttle between neighboring cells is the mechanism that provides redox and nutrient balance, and thus ferroptotic resistance in SLC7A11 knock out PDAC cells (Meira et al., 2021)

E., Temm-Grove, C