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Enzymatic hydrolysis within the stomach and small intestine rapidly cleaves peptide bonds, while epithelial tight junctions restrict paracellular transport of larger, hydrophilic molecules

Anti-drug antibodies may develop against therapeutic peptides, particularly those that differ structurally from endogenous human peptides

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The Future of Peptide Therapy Summary: Legitimate therapeutic peptides are here to staybut clinical translation must be evidence-led