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The evidence is still preliminary, and more robust trials are needed to confirm the association, says review co-author Pratibha Natesh, an endocrinologist at Warwick Medical School in Coventry, UK

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Cats with chronic renal disease may suffer mucosal damage from uremic toxins and increased gastric acid production secondary to hypergastrinemia (because of decreased renal metabolism of gastrin)

What to Expect When Switching: First 2-4 Weeks: Side effects may recur even if you tolerated the first medication well Nausea and GI symptoms are common during transition Appetite changes may feel different Weight loss may slow temporarily Weeks 4-12: Body adjusts to new medication Side effects typically improve Appetite suppression becomes consistent Weight loss resumes or accelerates (especially switching to tirzepatide) After 3 Months: Full effects of new medication apparent Can assess if switch was beneficial May adjust dose based on results and tolerance Switching Success Rates: Most patients successfully transition between medications