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Administration of exendin-4 ameliorated stress-induced defecation, decreased visceral pain sensitivity and increased the serum level of anti-inflammatory cytokine: interleukin-13 in the WistarKyoto rat strain, which was considered a model for irritable bowel syndrome [116]

For the UK market, oral semaglutide 14 mg was more cost-effective compared with sitagliptin 100 mg and empagliflozin 25 mg and superior as compared to liraglutide 1.8 mg daily dose for T2DM

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While all GLP-1 drugs influence appetite and metabolism, only some (like semaglutide and tirzepatide) are FDA-approved specifically for weight management