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Poutaraud et al., 2017) and human health (Kris-Etherton et al., 2002

The arginine substitution at position 3 greatly reduces the peptides affinity for IGFBPs by about 100-fold compared to native IGF-1

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Other non-entero-pancreatic hormone-based pharmacotherapies such as bimagrumab and growth differentiation factor 15 (GDF-15) are also under investigation