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Plasma hormone measurement All blood samples were collected by capillary EDTA tubes via the tail vein in free-moving, conscious animals

Patients who met eligibility criteria were enrolled in a single-blind, 2-week, dietary and exercise placebo lead-in period during which patients received metformin HCl (1500 to 3000 mg based on their pre-trial dose)

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82460237, 82060222), the Natural Science Foundation of Jiangxi Province, China (No