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Indeed, further studies to elucidate the prevalence of APAP-related hepatotoxic patients may be beneficial to identify the clinical stage of APAP hepatotoxicity in order to better triage patient treatment, improve disposition, and design the best follow-up

The combination was first characterized for safety and pharmacokinetics in a Phase 1b trial, [4] then advanced into the Phase 3a REDEFINE program

The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40

Cockerill et al., 2018)

This is a caution, not a settled finding but it is a reason to involve a clinician