Prospective studies integrating body composition trajectories, structured dietary assessment, and redox-relevant biomarkers during GLP-1RA therapy may clarify whether preservation of rate-limiting substrate modules supports lean mass maintenance and metabolic stability
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If retatrutide is authorised, wed expect criteria similar to current NHS policies for weight-management injections: a BMI threshold (with lower thresholds for some ethnic groups), presence of weight-related conditions (e.g., hypertension, OSA, prediabetes), and use alongside structured lifestyle support
Nature 523 , 561567 (2015)
