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Interestingly, single alanine amino acid substitutions of some interacting residues within the TMD had much larger effects on exendin-4 affinity than removal of the first 8 residues of the peptide, suggesting that peptide ECD and TMD interactions are correlated, such that non-optimal interactions with the TMD likely promote faster peptide dissociation from the ECD

Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives

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Abstract Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge

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