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This is particularly relevant in the aging brain, where insulin resistance and impaired glucose metabolism emerge years before overt cognitive symptoms

Dig Dis Sci 2008;53:30183025

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Within this context, it further considers incretin mimetics and phytomolecules, therapeutic strategies established in Type 2 Diabetes management as complementary, multi-target pharmacological approaches with potential to stabilize neuronal energy metabolism, restoring mitochondrial homeostasis, and mitigate S-associated neurodegenerative processes

Nanoemulsion improves hypoglycemic efficacy of berberine by overcoming its gastrointestinal challenge