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Retatrutide In the first phase 3 trial (TRIUMPH-4), participants lost an average of 28.7% of their body weight at 68 weeks on the highest dose (12mg), with the 9mg dose showing 26.4% weight loss

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Women using oral contraceptives should be counseled about this potential interaction and may need to consider alternative or additional contraceptive methods, particularly during the initial weeks of treatment when gastric emptying effects may be most pronounced

RV-8451, differentiated oral, muscle-preserving GLP-1 candidate for obesity Recent Highlights: In February 2026, Rivus stated it was entering a pivotal year, advancing HU6 in the AMPLIFY Phase 2 MASH trial while preparing the first clinical trial for RV-8451, its muscle-preserving oral GLP-1 candidate, designed to address the muscle-loss criticism leveled at existing GLP-1 therapies