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Nov 1: Mercks blockbuster Keytruda racked up another FDA approval Wednesday, as the company announced that the anti-PD-1 therapy is now authorizedin combination with gemcitabine and cisplatinto treat patients with locally advanced unresectable or metastatic biliary tract cancer (BTC)

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Given the wide array of information presented through this public comment process, we will take the technical recommendations, alternate methodological approaches, and other detailed feedback provided into consideration for future notice and comment rulemaking

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Paradoxically, liver-specific FASN knockout promoted hepatic steatosis in mice on a zero-fat diet [60], in which steatosis developed alongside defective PPAR signaling and with a phenotype that could be corrected by dietary fat or a PPAR agonist [60]