477 Similarly, other types of lymphocyte-B cells have been investigated to determine whether restoring B cell production in the bone marrow or reconstructing the peripheral B cell repertoire could enhance the immune responsiveness of elderly individuals to neoantigen challenges (NCT00863187) (Table 2)
Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression (41, 62, 63)
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