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A landmark clinical trial of semaglutide, published in 2021, found that participants experienced an average of 15% weight loss over the course of 68 weeks while those on placebo lost 2%

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Their efficacy stems from a multi-targeted mechanism: they ameliorate hepatic steatosis, potently reduce oxidative stress by scavenging ROS and improving redox status, and directly inhibit the activation of the central NF-B inflammatory pathway