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Achilles tendinopathy is especially vulnerable to this the mid-substance of the Achilles has the worst blood supply of any region in the tendon, which is exactly where most chronic degeneration occurs

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doi: 10.1158/1055-9965.epi-03-0193

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Meanwhile, mRNA levels of individual TET family members ( TET1 TET3 ) remained largely comparable between shCtrl and shGDH1 cells (Extended Data Fig