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Mini Reviews in Medicinal Chemistry

Our results demonstrated a significant reduction in inflammatory pathway activation in both the IMQ-induced psoriasis mouse model and the in vitro cell model

One advantage is that they do not cause skin thinning, which makes them useful for sensitive areas like the face or eyelids

To further support the in vivo findings, we conducted in vitro coculture experiments that mimic the microenvironment of TLS (Supplemental Figure 10A)

Since this study, several other publications highlighted the potential interest of Fisetin to treat different diseases related to senescence cells accumulation such as kidney fibrosis 20 or muscular dystrophy 21

doi: 10.1016/j.jtos.2017.05.006 302 BronAJDe PaivaCSChauhanSKBoniniSGabisonEEJainSet al