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The diabetic-ulcer study used daily application of a metered dose within a standardized wound-care protocol, including debridement, footwear, and diabetes-related education [3]

doi: 10.1515/cclm.2008.139 61 HakAEPolsHAVisserTJDrexhageHAHofmanAWittemanJC

Rare reports describe more significant reactions

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Levinthal argued that there is no need to search this vast space since the energy landscape is funnel-like, rather than flat, and thus can guide sampling toward the biological conformational basin