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Fuselier T, Mota de Sa P, Qadir MMF, Xu B, Allard C, Meyers MM, et al
Others may require ongoing treatment to prevent weight regain
Researchers theorize that combining appetite regulation, insulin signaling, and energy expenditure may create a broader metabolic effect than GLP-1-based activity alone a concept central to why triple-agonist research continues gaining momentum
The expression and distribution of FFARs such as GPR40, GPR119, and GPR120 in L and cells and glucose, along with their dual effects on insulin and GLP-1 secretion, have made them attractive therapeutic targets, leading to the development of agonists for these receptors for the treatment of T2DM [150,151,152,153,154]
Secondary analysis of renal end points in a cardiovascular safety trial of a DPP-4 inhibitor in patients with T2DM at high cardiovascular risk, showing that saxagliptin reduces albuminuria in a glucose-independent manner
News of the benefits spread by word of mouth and social media, with patients and doctors sharing click-charts with dosage recommendations
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