Gastrointestinal effects are the most frequently reported side effects and include: Nausea (1224% of patients): Often most pronounced during treatment initiation and dose escalation, typically improving over time Diarrhea (1323% of patients): May be transient or persistent, requiring dietary modifications Vomiting (611% of patients): Can lead to dehydration if severe or prolonged Constipation (617% of patients): May require increased fiber intake and hydration Abdominal pain or discomfort (610% of patients): Usually mild to moderate in severity Decreased appetite : Therapeutic effect but may be excessive in some individuals These gastrointestinal symptoms generally diminish over several weeks as the body adjusts to the medication
Reynolds Institute on Aging at the University of Arkansas for Medical Sciences Whats less widely known is that more than a third of people taking these meds, especially if theyre using them for weight loss only, will quit within a year, according to recent research published in JAMA Network Open
The FDA has required manufacturers to include pancreatitis warnings in prescribing information for all GLP-1 medications, though the exact causal relationship remains incompletely understood
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