However, prolonged or high-dose ketamine exposure induces a compensatory upregulation of NMDARs, increasing intracellular calcium ion influx and ROS production, ultimately leading to neuronal apoptosis ( In animal studies, antagonism of NMDA receptors in intermediate neurons of the forebrain and thalamus reduces GABAergic function
doi:10.3389/fphar.2024.1402138 Lawrence CB, Snape AC, Baudoin FMH, Luckman SM
the intramuscular multiple administration irritation test shows that intramuscular multiple injections have certain irritation to the biceps femoris of the rabbits, but have recoverability
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[DOI] [PubMed] [Google Scholar] 86.Smirnova, O
Network meta-analysis of novel glucose-lowering drugs on risk of acute kidney injury