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DOI: 10.1186/1475-2891-13-5

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crassa egt-1 ortholog), which encodes a trimodular enzyme, completely abolished EGT biosynthesis, as determined by RP-HPLC and LC-MS/MS (Sheridan et al., 2016)

High levels of this chemokine can upregulate nicotinamide adenine dinucleotide phosphate-oxidase 1 (NOX1) in glial cells, triggering the production of reactive oxygen species (ROS) and potentiating glutamate-induced neuronal death 29

While it is true that DCZ0415 is not yet a clinically approved agent, it has consistently demonstrated both in vitro and in vivo efficacy and specificity in cancer, as shown in our studies [1, 2] and other previous publications [44,45,46]