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However, pathologic conditions activate microglia to increase cytokine production, resulting in either a pro-inflammatory or anti-inflammatory phenotype, classically defined as M1 and M2, respectively, (Woodburn et al., 2021

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The pain and swelling are due to the friction between bones caused by loss of cartilage and inflammation of the ligaments, tendons, or synovial membrane covering the joint cavity

In preliminary experiments, we tested that -glutamylcysteine synthesis was linear with the incubation time at least up to 20 min