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doi: 10.1016/j.ebiom.2023.104642, 3 AronneL

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Nine tendons and the median nerve must pass through this remarkably small space, explaining why even minor swelling causes significant problems

MT1 is substantially more selective for MC1R, which explains MT2's broader side-effect profile including nausea, spontaneous erections, and appetite changes

Proc Soc Exp Biol Med 157:342347 Gennaro R, Dewald B, Horisberger U, Gubler HU, Baggiolini M (1983) A novel type of cytoplasmic granule in bovine neutrophils