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Even with insurance, cost-related nonadherence remains prevalent, with patients often skipping doses, delaying fills, or not obtaining needed medications due to cost [133, 134]

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doi:10.1016/j.jneuroim.2014.06.025

The best course of treatment for melasma would be sun avoidance, using a mineral-based sunscreen combined with topical skincare products with hydroquinone, Retinoids, Vitamin C, Kojic Acid, Niacinamide, Alpha Hydroxy Acids, Beta Hydroxy Acids, Azelaic Acid, and Arbutin

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