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Most require BMI 30, or BMI 27 with at least one obesity-related comorbidity (hypertension, dyslipidemia, prediabetes, sleep apnea, osteoarthritis)

To date, preclinical HFpEF models have primarily utilized single perturbations to replicate the human HFpEF phenotype

Individuals with hypothyroidism on replacement therapy may experience changes in their TSH and free T4 levels as they lose weight, because adipose tissue influences how thyroid hormones circulate and are utilized

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Blood sugar fluctuations: Alcohol can cause rapid spikes and crashes in blood sugar levels, counteracting the glucose-regulating benefits of Semaglutide