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It is primarily regulated by two endogenous hormones with opposite physiological functions: leptin, the energy surfeit hormone, and ghrelin, the hunger hormone, both of which are involved in controlling energy balance and obesity

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Humans express eight different glutathione peroxidase genes identified as GPX1 through GPX8, with five of these enzymes (GPX1, GPX2, GPX3, GPX4, and GPX6) having been demonstrated to harbor selenocysteine residues

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Moreover, calorie restriction induces autophagy in liver cells, promoting hepatic insulin sensitivity and mitigating fatty liver disease, a prevalent consequence of T2D [77]