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Free cellular iron is a cofactor for lipoxygenases (LOX), a central player in ferroptosis

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According to the American Diabetes Association, prediabetes can be defined by a condition of impaired fasting glucose, characterized by a fasting blood glucose concentration between 100 mg/dL and 125 mg/dL and/or a condition of impaired glucose tolerance, characterized by a 2-hour blood glucose concentration 140 mg/dL following an oral glucose tolerance test (56)

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Acids 16 , 313325 (2019)

This matters most for tendons, ligaments, and cartilage, which have limited blood supply and dont respond well to standard anti-inflammatory approaches