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Notably, FKBP8 translocates from damaged, acidified mitochondria to the endoplasmic reticulum to avoid degradation, indicating that this translocation relies on the weakly basic sequence at the C-terminal end, thereby inhibiting apoptosis during autophagy [23]

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While previous fiber photometry results showed that administration of GLP-1 or liraglutide did not significantly alter ARC AgRP/NPY neuron calcium signals post 30-minute injection, after 2 hours post-injection, the rapid suppression of AgRP calcium signals after cognition of food was indeed attenuated by liraglutide [49,82,85]

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