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doi: 10.1126/sciadv.1400121 226 NaculLde BarrosBKingdonCCCliffJMClarkTGMudieKet al

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NAD(+) administration decreases doxorubicin-induced liver damage of mice by enhancing antioxidation capacity and decreasing DNA damage

The structural modifications incorporated into CJC-1295 include D-alanine at position 2 to enhance resistance to enzymatic degradation, glutamine at position 8 to reduce asparagine rearrangement and prevent amide hydrolysis to aspartic acid, alanine at position 15 to enhance bioactivity, and leucine at position 27 to prevent methionine oxidation