Effectiveness depends on the drug, the dose you reach, and how consistently you take it
Since it works systemically, it may help improve overall body skin tone
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E.NegidaY.CadriS.et al (2024)
Interestingly, the increases in MEK1/2 and p70S6K1 phosphorylation were also observed when cells were subjected to the treatment of AKT inhibitor or genetic knockdown of AKT2 but not AKT1, suggesting that AKT2 inhibition stimulates MEK1/2 phosphorylation to activate p70S6K1
Exploratory analyses also suggested potential benefits for all-cause mortality and kidney outcomes , particularly when tirzepatide was compared indirectly with historical placebo data
