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We assume that the flexibility of the polypeptide backbone and the targeting ligands could help the uptake and permeability of the 3-PLGs with similarly greater size at the BBB model

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But the evidence is mixed, study quality is variable, and benefits in pregnancy or live birth are much harder to prove consistently

[3] Orforglipron was approved for medical use in the United States in April 2026

In other words, it is possible for patients to maintain weight while stopping the medication but some patients may also gain weight at a faster rate or a greater degree than what is seen in the scientific studies, says Lofton