Therapeutic Rationale Behind the Standard Dose The 1000 mcg dose is chosen for its quick fix of vitamin B12
A frequently repeated "half-life ~12.8 days" figure circulates in vendor copy as a rationale for spaced or cyclical dosing
Semaglutide use: Semaglutide itself slows gastric emptying, which may indirectly impair your bodys ability to absorb vitamin B12, leading to a vitamin B12 deficiency
Blood, 112(6), pp.2214-2221
Course Duration: 1-2 months
J Diabetes Investig 7(1Suppl 1):7679 Toki S, Goleniewska K, Reiss S, Zhang J, Bloodworth MH, Stier MT et al (2018) Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo