Over a few months, the full effects show up
This can sometimes lead to more rapid effects, but also comes with a greater risk of side effects such as joint pain, insulin resistance, Carpal tunnel syndrome, joint and muscle pain, swelling or arms and legs, and gynecomastia (enlarging of breast tissue in men)
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Tahara Y, Hirota M, Shima K, et al
Gene delivery of IL-1Ra through a regenerative scaffold or direct delivery of IL-1Ra via nanoparticle carriers are both promising options for cartilage repair in patients with post-surgical inflammation and other chronic inflammatory conditions

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