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The authors of one trial (95) included in the above-mentioned meta-analysis (89) noted that little cognitive decline was observed in the placebo group over their two-year trial, which may have limited their power to detect an effect of the B-vitamin intervention (95)

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And it concludes with diligent observation

The classification of the molecular subclass was done by microarray (confirmed by qRT-PCR analysis) and histopathology analysis, as previously described (3, 90)