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AREGETVVPG reduces intracellular reactive oxygen species (ROS) production, inhibits phosphorylation of PKC, AKT, and Erk 1/2, and inhibits Nox 4 protein expression to protect hyperglucose-induced vascular smooth muscle cells (VSMC) oxidative stress (116)

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Compound 3 was isolated by silica gel column chromatography using a dichloromethane/methanol (DCM:MeOH = 40:1, V/V) eluent (yield: 75%)