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Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79

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In June 2022 the UK medicines regulator updated its advice: the MHRA now lists low vitamin B12 as a common side effect of metformin, meaning it can affect up to one in ten people taking it

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