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The FDA evaluates nominated substances using a balancing test that considers physical and chemical characterization, safety issues, available evidence of effectiveness or lack of effectiveness, and historical use in compounding

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In conclusion, BPC-157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway