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Broader metabolic changesincluding fat loss and muscle preservationdevelop over 4-12 weeks as appetite suppression creates a consistent calorie deficit

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Mice with Glp1r deletion under the regulation of the Tie2 gene promoter ( Tek ) were generated by crossing Tg(Tek-Cre)1Ywa mice (Tie2-Cre) from The Jackson Laboratory (stock 008863) with Glp1r fl/fl mice (48)