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Skin cell turnover takes 4-6 weeks biologically, and melanin distribution changes gradually as new cells replace old ones

1 Introduction Bone defects are commonly encountered in clinical practice and can arise from various causes, including trauma (e.g., fractures), age-related bone loss (e.g., osteoporosis), infections (e.g., osteomyelitis and periodontitis), cancer (e.g., surgical resection), genetic diseases (e.g., inherited bone marrow failure syndrome), and congenital defects (e.g., cleft palate)

It is not intended to diagnose, treat, cure or prevent disease.

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This is why we measure IGF-1 at baseline and during treatment rather than dosing to symptom report alone

ACS Synth Biol 8(7):15641567