Henze D, Doecke WD, Hornung D, Agueusop I, von Ahsen O, Machens K, et al
Ursini, F
This medicine is only for use in children, infants and newborns below 12 years of age
In-Vitro & Cellular Studies Laboratory experiments using cell cultures and isolated tissues have explored molecular and cellular mechanisms associated with: angiogenesis-related signaling fibroblast migration and behavior extracellular-matrix organization actin cytoskeleton interactions (TB4-related) inflammatory mediator expression These studies help identify biological pathways but do not replicate the complexity of whole-organism responses
In vitro, we found that in PSCs, high ROS accumulation attributed to high glucose was associated with PSC activation, which was characterized by increased expression of -SMA, accelerated migration, and increased synthesis of ECM proteins such as collagen I, all of which were rescued by GSH treatment
PMCID: PMC12307007