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Felici, M

These include high-fat diets, lack of exercise, too much alcohol, and immune system challenges [4]

Alternatively, nuclear receptor coactivator 4 (NCOA4)-mediated degradation of the ferritin phagocytosis pathway can occur, resulting in increased iron storage, followed by Fenton reaction/mitochondrial damage/LOX function, leading to increased iron concentration in the active iron pool (LIP) [37]

JAK are a part of the JAK/STAT pathway, and this signaling is continuously activated, resulting in the elevated level of MMPs and apoptotic chondrocytes in RA synovial joints (130)

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