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Weight loss and reduced appetite Research involving human participants has demonstrated that glucagon-like peptide-1 receptor agonists contribute to weight loss and appetite suppression through multiple mechanisms
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In patients with DM2 the incretin response is diminished, but the insulinotropic effect of GLP-1 is conserved.28 Under normal conditions GLP-1 has a short half-life (approximately 2 min), as it is rapidly degraded by dipeptidylpeptidase 4, so GLP-1 analogues resistant to this enzyme have been developed for the treatment of DM2.29 arGLP-1: glucagon-like peptide 1 receptor agonist
Current Opinion in Psychiatry 28, 712.CrossRefGoogle Scholar Williams, DL, Lilly, NA, Edwards, IJ, Yao, P, Richards, JE and Trapp, S (2018) GLP-1 action in the mouse bed nucleus of the stria terminalis
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