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Researchers and clinicians using it do so based on extrapolation from animal data and accumulating clinical experience rather than proven efficacy in humans

Dosing and Protocol Mistakes Starting Too High: Beginners sometimes start with aggressive doses of 1 mg or higher based on the assumption that more is better

The Gut-Immune Axis: Where Healing Begins Patients often wonder if they should have testing for leaky gut however a less expensive and more practical solution is to do a short term trial of an elimination diet specifically avoiding the types of foods that cause intestinal permeability (wheat, black pepper etc) and items like medications (ibuprofen, oral contraceptive pill etc) which are known to cause intestinal permeability issues

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For pigmentation and melasma, this represents a meaningful shift in approach