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Abstract Glucose 6-phosphate dehydrogenase deficiency (G6PD-d) is the most common enzymopathy in the world, occurring in 58% of the global population (half a billion people)

doi: 10.1016/s0092-8674(00)80949-6

Wei S, Ma W, Li X, Jiang C, Sun T, Li Y et al (2020) Involvement of ROS/NLRP3 inflammasome signaling pathway in doxorubicin-induced cardiotoxicity

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The progressive loss of nephrons reduces renal 1-hydroxylase activity, limiting the production of active 1,25-dihydroxyvitamin D (1,25(OH)D), whereas urinary loss of vitamin D-binding protein (VDBP) due to proteinuria further exacerbates 25(OH)D deficiency (3)