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2011, Khavinson et al 2008), and with the linker histone protein H1 (H1.3 and H1.6) thereby influencing epigenetic regulation and expression of genes (Khavinson et al 2020)

It is the vehicl...

Nature, 583: 590-595

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While the exact mechanisms remain to be agreed upon, both in vitro and in vivo experiments suggested several potential pathways for APOE4, including enhancing A production (promoting APP transcription and processing), facilitating A aggregation (interaction with soluble and fibrillary A aids in seeding/oligomerization/protofibril formation), and impairing A clearance (disrupted glial and enzymatic A degradation functions, and A removal rate from the brain)