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Geriatric Use XIGDUO XR No XIGDUO XR dosage change is recommended based on age

In the SURPASS-2 trial, tirzepatide outperformed semaglutide in reducing A1C levels

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The NO pathway is especially important in endothelial cells, as PKA activates NO synthase (NOS), which can produce more nitric acid and does result in reduced small intestine, large intestine, and colon motility